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The main aim of of the project is to create a library of specific antioxidative protectormolecules and to test properties (including a protective potency) of the representatives of library both in vitro and on animal models (brain total ischemia model, model for parkinsonism, Langendorff's model, brain focal ischemia model) using updated biochemical methods and markers, what results in development of effective neuroprotectors. The importance and reality of main aim of project is based on the following circumstances: 1) creating and using specific antioxidative protectormolecules is a highly perspective scientific-practical world-trend; 2) prolonged severe OS has one of the key-positions in intensive adverse progress of neurodegenerative diseases, strokes, ischemic or traumatic damages of brain, arteriosclerosis and ischemia/reperfusion damages and thereby the investigation of OS and creating and using possible antioxidative protectormolecules had achieved more and more attention; 3) we have an experience, competence and co-operation for OS-related investigation, for designing of protectormolecules and for investigation of protectionmechanisms on animal models. |