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The main aim of the work is to study cell and organ damage induced by acute and chronic ethanol administration and ethanol withdrawal syndrome in humans and laboratory animals. The second main aim of the work is to study the effects of nitric oxide synthase (NOS) inhibitors, neurosteroids acting at GABAA receptor-chloride ionophore complex, glucocorticoids and glucocorticoid antagonists on the signs of ethanol withdrawal and on the cell and organ damage induced by ethanol. If we demonstrate the effects of NOS inhibitors, neurosteroids and glucocorticoids on the signs of ethanol withdrawal and on the cell and organ damage it helps to elucidate the mechanism of genesis of ethanol withdrawal. The results of the work may help to find new agents for the attenuation of ethanol withdrawal signs in man and for prevention of organ damage induced by ethanol withdrawal. |